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ThinkMind // BIOTECHNO 2016, The Eighth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies // View article biotechno_2016_2_20_60019


Computational Analysis of the Linear Motif Mediated Subversion of the Human Protein Synthesis Machinery

Authors:
Andrés Becerra Sandoval
Víctor Andrés Bucheli Guerrero
Pedro Antonio Moreno Tovar

Keywords: virus; host; protein; interaction; short; linear; motif; prediction; eukarya; protein-synthesis; subversion

Abstract:
We argue that virus-host interactions mediated by short linear motifs can be used to analyze common viral attack strategies. In this direction we develop a method for predicting interactions between human protein-synthesis machinery and viral proteins mediated by linear motifs in order to study common protein-synthesis subversion strategies. The method consists in finding viral instances of host linear motifs. We filter these instances by conservation in viral sequences, location in protein disordered regions and scarcity in randomized protein sets. With the filtered motifs we deduce virus-host interactions using the motif-domain associations in the Eukaryotic Linear Motifs (ELM) database. We validate the results against the Linear Motif mediated Protein Interaction Database (LMPID) and obtain a network of interactions between the human protein-synthesis machinery proteins and viruses influenza AH1N1, Dengue1, Ebola, MERS, Rotavirus, WestNile, and Zika.

Pages: 23 to 27

Copyright: Copyright (c) IARIA, 2016

Publication date: June 26, 2016

Published in: conference

ISSN: 2308-4383

ISBN: 978-1-61208-488-6

Location: Lisbon, Portugal

Dates: from June 26, 2016 to June 30, 2016

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