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ThinkMind // BIOTECHNO 2021, The Thirteenth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies // View article biotechno_2021_1_10_70020


Genetic Markers Associated with Anemia in Individuals with Sickle Cell Disease in Tanzania

Authors:
Liberata Alexander Mwita
Raphael Zozimus Sangeda
Upendo Masamu
David Dynerman

Keywords: Sickle cell disease; Anemia; Genome Wide Association Studies.

Abstract:
Sickle cell disease is a global health problem, a genetic disease which affects many people, particularly common among those whose ancestors came from sub-Saharan Africa. All individuals with sickle cell disease experience anemia which increases the morbidity and mortality. This research aims to identify genetic variants associated with anemia in individuals with sickle cell disease. In the long-term this will contribute towards efforts to improve the life expectancy of individuals by quickly identifying single nucleotide polymorphisms related to anemia in sickle cell disease and enabling better prediction of the severity of anemia that the individual will experience which enable better preventive treatment. Quality control of the Genome Wide Association Studies data and association between anemia and the genotype data were performed using PLINK software and will be presented. Designing of imputation and replication study of the Genome Wide Association Studies data is in progress. The analysis will identify single nucleotide polymorphisms and genes linked to anemia in individuals with sickle cell disease. The results can also be compared with single nucleotide polymorphisms candidates from other studies.

Pages: 1 to 3

Copyright: Copyright (c) IARIA, 2021

Publication date: May 30, 2021

Published in: conference

ISSN: 2308-4383

ISBN: 978-1-61208-859-4

Location: Valencia, Spain

Dates: from May 30, 2021 to June 3, 2021

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